Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland.
Department of Hygiene and Epidemiology, Faculty of Medicine and Health Science, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.
Int J Environ Res Public Health. 2019 Jul 27;16(15):2687. doi: 10.3390/ijerph16152687.
The polymorphism located in the gene is one of the most widely studied polymorphisms in regards to the genetics of behavior and addiction. The aim of our study was to analyze this polymorphism with regard to personality characteristics and anxiety measured by means of the Personality Inventory-(NEO Five-Factor Inventory-NEO-FFI) and the State-Trait Anxiety Inventory (STAI) in polysubstance addicted subjects. The study group consisted of 600 male volunteers, including 299 addicted subjects and 301 controls. Psychiatrists recruited members for both groups. Addiction was diagnosed in the case group. In the control group mental illness was excluded. The same psychometric test and genotyping using the real-time PCR (polymerase chain reaction) method was performed for both groups. The results were investigated by means of multivariate analysis of the main effects Multi-factor ANOVA. Significantly higher scores on the scale of STAI state and Neuroticism and Openness traits, as well as lower scores on the scales of Extraversion, Agreeability, and Conscientiousness, were found in the case group subjects, compared to the controls. Differences in frequency of genotypes and alleles of polymorphism between the studied groups were not found. Multi-factor ANOVA of addicted subjects and control subjects and the ANKK1 Taq1A variant interaction approximated the statistical significance for the STAI state. The main effects ANOVA of both subjects' groups were found for the STAI state and trait, the Neuroticism scale, the Extraversion scale, and the Agreeability scale. The main effects approximated the statistical significance of the STAI trait. Our study shows not only differences in personality traits between addicted and non-addicted subjects, but also the possible impact of on given traits and on addiction itself.
位于 基因中的多态性是行为和成瘾遗传学中研究最广泛的多态性之一。我们的研究目的是分析该多态性与人格特征和焦虑之间的关系，使用人格量表-(NEO 五因素量表-NEO-FFI)和状态-特质焦虑量表(STAI)测量。研究组包括 600 名男性志愿者，其中 299 名成瘾者和 301 名对照组。精神科医生招募了两组的成员。在病例组中诊断出成瘾。在对照组中排除了精神疾病。对两组进行了相同的心理测试和使用实时 PCR(聚合酶链反应)方法的基因分型。通过主效应多因素方差分析(多因素方差分析)对结果进行了调查。与对照组相比，病例组的 STAI 状态和神经质和开放性特质评分显著较高，而外向性、宜人性和尽责性评分显著较低。在研究组之间未发现 多态性的基因型和等位基因频率差异。对成瘾者和对照组进行多因素方差分析和 ANKK1 Taq1A 变体相互作用接近 STAI 状态的统计学意义。两组被试的主效应方差分析发现 STAI 状态和特质、神经质量表、外向性量表和宜人性量表存在差异。主效应接近 STAI 特质的统计学意义。我们的研究不仅显示了成瘾者和非成瘾者之间人格特征的差异，还显示了 对特定特征和成瘾本身的可能影响。
