噬菌体展示肽库技术在鉴定功能靶向肽中的潜力。
Potential of phage-displayed peptide library technology to identify functional targeting peptides.
机构信息
SAIC-Frederick, Inc., Molecular Targets Development Program, NCI-Frederick, Frederick, Maryland 21702, USA.
出版信息
Expert Opin Drug Discov. 2007 Apr;2(4):525. doi: 10.1517/17460441.2.4.525.
Abstract
Combinatorial peptide library technology is a valuable resource for drug discovery and development. Several peptide drugs developed through phage-displayed peptide library technology are presently in clinical trials and the authors envision that phage-displayed peptide library technology will assist in the discovery and development of many more. This review attempts to compile and summarize recent literature on targeting peptides developed through peptide library technology, with special emphasis on novel peptides with targeting capacity evaluated in vivo.
摘要
组合肽文库技术是药物发现和开发的宝贵资源。目前有几种通过噬菌体展示肽文库技术开发的肽类药物正在临床试验中，作者设想噬菌体展示肽文库技术将有助于发现和开发更多的药物。本文综述了近年来利用肽文库技术开发的靶向肽的文献，特别强调了体内评估具有靶向能力的新型肽。
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本文引用的文献
1
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs.利用噬菌体展示肽库开发肿瘤靶向药物。
Int J Pept Res Ther. 2006 Mar;12(1):79-91. doi: 10.1007/s10989-005-9002-3. Epub 2006 Mar 3.
2
Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.使用单珠单化合物文库对CD21结合肽进行两步荧光筛选以及对N-(2-羟丙基)甲基丙烯酰胺共聚物-肽缀合物的结合特性进行研究。
Biomacromolecules. 2006 Nov;7(11):3037-46. doi: 10.1021/bm060508f.
3
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FASEB J. 2006 Dec;20(14):2597-9. doi: 10.1096/fj.06-6572fje. Epub 2006 Oct 25.
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