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噬菌体展示肽库技术在鉴定功能靶向肽中的潜力。

Potential of phage-displayed peptide library technology to identify functional targeting peptides.

机构信息

SAIC-Frederick, Inc., Molecular Targets Development Program, NCI-Frederick, Frederick, Maryland 21702, USA.

出版信息

Expert Opin Drug Discov. 2007 Apr;2(4):525. doi: 10.1517/17460441.2.4.525.

DOI:10.1517/17460441.2.4.525
PMID:20150977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2818987/
Abstract

Combinatorial peptide library technology is a valuable resource for drug discovery and development. Several peptide drugs developed through phage-displayed peptide library technology are presently in clinical trials and the authors envision that phage-displayed peptide library technology will assist in the discovery and development of many more. This review attempts to compile and summarize recent literature on targeting peptides developed through peptide library technology, with special emphasis on novel peptides with targeting capacity evaluated in vivo.

摘要

组合肽文库技术是药物发现和开发的宝贵资源。目前有几种通过噬菌体展示肽文库技术开发的肽类药物正在临床试验中，作者设想噬菌体展示肽文库技术将有助于发现和开发更多的药物。本文综述了近年来利用肽文库技术开发的靶向肽的文献，特别强调了体内评估具有靶向能力的新型肽。

相似文献

[1]
Potential of phage-displayed peptide library technology to identify functional targeting peptides.

Expert Opin Drug Discov. 2007-4

[2]
Is phage display technology on target for developing peptide-based cancer drugs?

Curr Drug Discov Technol. 2004-6

[3]
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs.

Int J Pept Res Ther. 2006-3

[4]
Advancement and applications of peptide phage display technology in biomedical science.

J Biomed Sci. 2016-1-19

[5]
Phage display biopanning and isolation of target-unrelated peptides: in search of nonspecific binders hidden in a combinatorial library.

Amino Acids. 2016-12

[6]
Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.

BMC Biotechnol. 2007-10-5

[7]
Phage display as a technology delivering on the promise of peptide drug discovery.

Drug Discov Today. 2013-12

[8]
Tumor-targeting peptides from combinatorial libraries.

Adv Drug Deliv Rev. 2017-2

[9]
Biased selection of propagation-related TUPs from phage display peptide libraries.

Amino Acids. 2017-8

[10]
Phage displayed biomolecules as preventive and therapeutic agents.

Curr Pharm Biotechnol. 2001-9

引用本文的文献

[1]
Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands.

Int J Mol Sci. 2021-2-5

[2]
A Global Review on Short Peptides: Frontiers and Perspectives.

Molecules. 2021-1-15

[3]
Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications.

Cancer Gene Ther. 2020-11

[4]
Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery.

Molecules. 2019-4-25

[5]
Selection platforms for directed evolution in synthetic biology.

Biochem Soc Trans. 2016-8-15

[6]
Recent Advances Toward the Discovery of Drug-Like Peptides De novo.

Front Chem. 2015-12-18

[7]
Drugs derived from phage display: from candidate identification to clinical practice.

MAbs. 2014

[8]
Comparison of two peptide radiotracers for prostate carcinoma targeting.

Clinics (Sao Paulo). 2012

[9]
Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications.

Curr Pharm Des. 2010

[10]
Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.

BMC Biotechnol. 2007-10-5

本文引用的文献

[1]
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs.

Int J Pept Res Ther. 2006-3

[2]
Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.

Biomacromolecules. 2006-11

[3]
A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin.

FASEB J. 2006-12

[4]
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.

N Engl J Med. 2006-10-19

[5]
Identification of three novel peptides that inhibit CD40-CD154 interaction.

Mod Rheumatol. 2005

[6]
Baculovirus display: a multifunctional technology for gene delivery and eukaryotic library development.

Adv Virus Res. 2006

[7]
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.

Neoplasia. 2006-9

[8]
Identification of oligopeptides binding to peritoneal tumors of gastric cancer.

Cancer Sci. 2006-10

[9]
Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia.

Exp Hematol. 2006-10

[10]
Tumor specific phage particles promote tumor regression in a mouse melanoma model.

Cancer Immunol Immunother. 2007-5

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