来自组合文库的肿瘤靶向肽。
Tumor-targeting peptides from combinatorial libraries.
作者信息
Liu Ruiwu, Li Xiaocen, Xiao Wenwu, Lam Kit S
机构信息
Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA.
Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA; Division of Hematology & Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.
出版信息
Adv Drug Deliv Rev. 2017 Feb;110-111:13-37. doi: 10.1016/j.addr.2016.05.009. Epub 2016 May 19.
Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges in fighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver therapeutics and imaging probes to the primary or metastatic tumor sites. Combinatorial libraries such as phage-display and one-bead one-compound (OBOC) peptide libraries are powerful approaches in discovering tumor-targeting peptides. This review gives an overview of different combinatorial library technologies that have been used for the discovery of tumor-targeting peptides. Examples of tumor-targeting peptides identified from each combinatorial library method will be discussed. Published tumor-targeting peptide ligands and their applications will also be summarized by the combinatorial library methods and their corresponding binding receptors.
癌症是全球主要的致死原因之一。对抗癌症的两大最大挑战是早期检测以及无副作用或副作用最小的有效治疗方法。靶向疗法和分子成像在临床上的广泛应用需要高亲和力、肿瘤特异性的药物作为有效的靶向载体，将治疗药物和成像探针递送至原发性或转移性肿瘤部位。诸如噬菌体展示和单珠单化合物（OBOC）肽库等组合文库是发现肿瘤靶向肽的有力方法。本综述概述了已用于发现肿瘤靶向肽的不同组合文库技术。将讨论从每种组合文库方法中鉴定出的肿瘤靶向肽的实例。已发表的肿瘤靶向肽配体及其应用也将按组合文库方法及其相应的结合受体进行总结。
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