Kaleda V G, Lebedeva I S, Barkhatova A N, Omel'chenko M A, Golubev S A, Sidorova M A
Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Neurosci Behav Physiol. 2010 Mar;40(3):339-45. doi: 10.1007/s11055-010-9261-0.
The therapeutic dynamics of neuropsychological and neurophysiological markers of impairments to cognitive functions were studied in groups of patients with first episodes of juvenile endogenous psychosis (90 patients). At the initial stage of remission, subjects were found to show improvements in processes associated with voluntary regulation of cognitive functions (due to the activity of extensive networks of cortical and subcortical structures), while more automatic processes (associated mainly with the temporal areas of the brain) remained abnormal. Changes in neurocognitive anomalies during the onset of remission were also identified in groups of patients in whom episodes had different syndromal structures - catatonic, hallucinatory-delusional, and affective-delusional.
对首次发作的青少年内源性精神病患者组（90例患者）的认知功能障碍的神经心理学和神经生理学标志物的治疗动态进行了研究。在缓解初期，发现受试者与认知功能的自主调节相关的过程有所改善（归因于广泛的皮质和皮质下结构网络的活动），而更多的自动过程（主要与大脑颞叶区域相关）仍存在异常。在发作具有不同综合征结构（紧张性、幻觉妄想性和情感妄想性）的患者组中，也发现了缓解期开始时神经认知异常的变化。
