Department of Chemistry, University of Calcutta, Kolkata-700 009, India.
Chem Biodivers. 2010 Feb;7(2):363-75. doi: 10.1002/cbdv.200900050.
Three structurally different types of small peptides, namely, i) Boc-Ile-Aib-Ile-OMe (Aib=alpha-aminoisobutyric acid), ii) Boc-Xx-m-aminobenzoic acid (Xx=beta-Ala and gamma-aminobutyric acid), and iii) Boc-Xx-m-nitroaniline, were found to exhibit beta-sheet-mediated fibrillogenesis in the solid state, revealed by FT-IR, single-crystal X-ray diffraction, and FE-SEM studies. Interestingly, the fibrils grown from peptides 2 and 3 were found to bind with the physiological dye Congo red, a characteristic feature of amyloid fibrils.
三种结构不同的小肽，即 i） Boc-Ile-Aib-Ile-OMe（Aib=alpha-氨基异丁酸），ii） Boc-Xx-m-氨基苯甲酸（Xx=beta-丙氨酸和 gamma-氨基丁酸），和 iii） Boc-Xx-m-硝基苯胺，被发现具有固态中介导β-折叠的纤维形成，这通过 FT-IR、单晶 X 射线衍射和 FE-SEM 研究得到证实。有趣的是，从肽 2 和 3 生长的纤维被发现与生理染料刚果红结合，这是淀粉样纤维的特征。
