School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG6 6AD, United Kingdom.
Langmuir. 2010 May 18;26(10):7590-7. doi: 10.1021/la904403k.
A series of amphiphilic copolymers were synthesized by free-radical copolymerization of N-vinylpyrrolidone (NVP) with vinyl propyl ether (VPE), and the structure of the copolymers was characterized by elemental analysis and gel permeation chromatography. The reactivity of VPE in copolymerization was found to be significantly lower than the reactivity of NVP, which resulted in a decrease of copolymers' yields and molecular weights with higher content of VPE in the feed mixture. An investigation of the behavior of the copolymers in aqueous solutions at different temperatures by dynamic light scattering revealed the presence of lower critical solution temperature, which depending on the content of VPE ranged within 23-38 degrees C. Aqueous solutions of these copolymers were studied by fluorescent spectroscopy with pyrene as a polarity probe to reveal the formation of hydrophobic domains. The copolymers were found to be useful for enhancing the solubility of riboflavin in water.
一系列的两亲性共聚物通过自由基共聚的 N-乙烯基吡咯烷酮（NVP）与乙烯基丙基醚（VPE），和共聚物的结构通过元素分析和凝胶渗透色谱进行了表征。发现 VPE 的反应性在共聚反应中明显低于 NVP 的反应性，这导致了共聚物产率和分子量的降低，而进料混合物中 VPE 的含量较高。通过动态光散射研究了共聚物在不同温度下的水溶液行为，发现存在较低的临界溶液温度，其范围取决于 VPE 的含量在 23-38°C 之间。通过荧光光谱法用芘作为极性探针研究了这些共聚物的水溶液，以揭示疏水区的形成。发现这些共聚物可用于提高核黄素在水中的溶解度。
