高效、区域选择性合成 5-羟基-2-异恶唑啉：异恶唑、β-内酰胺和γ-氨基醇的多功能合成子。
Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols.
机构信息
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
出版信息
J Org Chem. 2010 Mar 19;75(6):1961-6. doi: 10.1021/jo1000065.
PMID:20151710
Abstract
An efficient and highly regioselective protocol was developed for the preparation of 5-hydroxy-2-isoxazolines, which have been proved to be versatile synthons for isoxazles, beta-hydroxy oximes, and gamma-amino alcohols. Beta-lactams, commonly embedded in the skeletons of bioactive natural products, were also synthesized in two steps from beta-hydroxy oximes, providing a new strategy for the synthesis of this kind of compounds.
摘要
开发了一种高效且高度区域选择性的方法来制备 5-羟基-2-异恶唑啉，已证明它们是异恶唑、β-羟基肟和γ-氨基醇的多功能合成子。β-内酰胺通常嵌入生物活性天然产物的骨架中，也可以通过β-羟基肟两步合成，为这类化合物的合成提供了新策略。
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