从咪唑酸酯烯胺酮无金属级联合成不对称2-氨基嘧啶。
Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones.
作者信息
Cui Xue, Ma Jianting, Zeng Tingting, Xu Junyu, Li Youbin, Wang Xuesong
机构信息
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University Haikou 571199 P. R. China
出版信息
RSC Adv. 2021 Jul 14;11(39):24247-24253. doi: 10.1039/d1ra04319f. eCollection 2021 Jul 6.
A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
已开发出一种从咪唑酸酯烯胺酮方便地无金属合成不对称2-氨基嘧啶的方法。在此过程中，以中等至优异的产率合成了各种结构的2-氨基嘧啶以及4,5-二氢异恶唑-5-醇和吡唑。还为该串联反应提出了一个合理的机理。该方法是合成不对称2-氨基嘧啶的有效策略。
Zotero 插件