可乐定和育亨宾对健康志愿者瞳孔对光反射及卡巴胆碱诱发出汗的影响。
Effects of clonidine and yohimbine on the pupillary light reflex and carbachol-evoked sweating in healthy volunteers.
作者信息
Morley M J, Bradshaw C M, Szabadi E
机构信息
Department of Psychiatry, University of Manchester.
出版信息
Br J Clin Pharmacol. 1991 Jan;31(1):99-101. doi: 10.1111/j.1365-2125.1991.tb03864.x.
Abstract
The effects of single doses of clonidine hydrochloride (200 micrograms), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double-blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by the treatments.
摘要
采用双盲交叉设计，在健康志愿者中研究了单次剂量的盐酸可乐定（200微克）、盐酸育亨宾（22毫克）、两种治疗方法联合使用以及安慰剂对某些自主神经功能的影响。可乐定延长了光反射的恢复时间，降低了收缩压，并降低了主观评定的警觉性；这些作用被育亨宾逆转。汗腺对卡巴胆碱的反应性不受这些治疗的影响。
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