可乐定治疗原发性高血压后，血流动力学和激素反应独立于镇静作用而发生。
The haemodynamic and hormonal responses after clonidine occur independently of sedation in essential hypertension.
作者信息
Kooner J S, Peart W S, Mathias C J
机构信息
Department of Medicine, St. Mary's Hospital and Medical School, London.
出版信息
Br J Clin Pharmacol. 1989 Sep;28(3):249-55. doi: 10.1111/j.1365-2125.1989.tb05423.x.
Abstract
- To investigate the contribution of sedation to the cardiovascular effects induced by clonidine, we studied patients with essential hypertension on two separate occasions when similar levels of sedation were induced by clonidine and nitrazepam. 2. After clonidine, there was a fall in blood pressure, heart rate, digital skin vascular resistance and plasma noradrenaline which is consistent with its ability to reduce sympathetic outflow. Dissociation of the circulatory/neurohormonal and sedative responses after clonidine indicated that sedation alone is not an important factor in the blood pressure lowering effect of clonidine. 3. The absence of a fall in blood pressure, heart rate, digital skin vascular resistance and plasma noradrenaline after nitrazepam further suggest that sedation did not influence the hypotensive response in essential hypertension.
摘要
- 为了研究镇静作用对可乐定所致心血管效应的影响，我们对原发性高血压患者进行了两项独立研究，分别在给予可乐定和硝西泮诱导出相似镇静水平的情况下进行观察。2. 给予可乐定后，血压、心率、手指皮肤血管阻力和血浆去甲肾上腺素水平均下降，这与其降低交感神经传出冲动的能力相符。可乐定给药后循环/神经激素反应与镇静反应的分离表明，单纯镇静并非可乐定降压作用的重要因素。3. 硝西泮给药后血压、心率、手指皮肤血管阻力和血浆去甲肾上腺素水平未下降，这进一步表明镇静并不影响原发性高血压患者的降压反应。
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