Queens University Belfast, School of Pharmacy, BT9 7BL, Northern Ireland, UK.
Expert Opin Drug Deliv. 2010 Apr;7(4):497-512. doi: 10.1517/17425240903579989.
In recent years, there has been a great deal of interest in the development of recombinant vectors based on biological motifs with potential applications in gene therapy. Several such vectors have been genetically engineered, resulting in biomacromolecules with new properties that are not present in nature.
This review briefly discusses the advantages and disadvantages of the current state-of-the-art gene delivery systems (viral and non-viral) and then provides an overview on the application of various biological motifs in vector development for gene delivery. Finally, it highlights some of the most advanced bio-inspired vectors that are designed to perform several self-guided functions.
This review helps the readers get a better understanding about the history and evolution of bio-inspired fusion vectors with the potential to merge the strengths of both viral and non-viral vectors in order to create efficient, safe and cost-effective gene delivery systems.
With the emergence of new technologies such as recombinant bio-inspired vectors, it may not take long before non-viral vectors are observed that are not just safe and tissue-specific, but even more efficient than viral vectors.
近年来，人们对基于具有基因治疗应用潜力的生物基序的重组载体的发展产生了浓厚的兴趣。已经对几种此类载体进行了基因工程改造，从而产生了具有自然界中不存在的新特性的生物大分子。
本篇综述简要讨论了当前最先进的基因传递系统（病毒和非病毒）的优缺点，然后概述了各种生物基序在基因传递载体开发中的应用。最后，它强调了一些最先进的仿生载体，这些载体旨在执行多种自我引导的功能。
本篇综述有助于读者更好地了解具有潜在融合病毒和非病毒载体优势的仿生融合载体的历史和演变，以创建高效、安全且具有成本效益的基因传递系统。
随着重组仿生载体等新技术的出现，用不了多久，人们就会发现非病毒载体不仅安全且具有组织特异性，而且甚至比病毒载体更有效。
