Paik Memorial Institute for Clinical Research, Department of Internal Medicine, College of Medicine, Inje University, Busan, South Korea.
Expert Opin Drug Deliv. 2010 Mar;7(3):321-30. doi: 10.1517/17425241003596329.
The use of ultrasound with microbubbles raises the possibility of an efficient and safe gene delivery.
This review summarizes the current state of the art of gene delivery by sonoporation under the following topics. First, the basic ultrasound parameters and the characteristics of microbubble in biological systems are discussed. Second, the extensions of sonoporation to other fields of gene delivery such as viral and non-viral vector are briefly reviewed. Finally, recent applications in an animal model for various diseases are introduced.
Information and comments on gene delivery by sonoporation or enhanced cell membrane permeability by means of ultrasound.
Ultrasound-mediated gene delivery combined with microbubble agents provides significant safety advantages over other methods of local gene delivery.
使用超声波与微泡提高了一个有效的和安全的基因传递的可能性。
这篇综述总结了目前的艺术状态的基因传递的声孔作用在以下主题。首先，基本的超声参数和微泡的特性在生物系统中进行了讨论。其次，声孔作用的扩展到其他领域的基因传递，如病毒和非病毒载体进行了简要的回顾。最后，最近的应用在动物模型中各种疾病进行了介绍。
信息和评论基因传递的声孔作用或增强细胞膜通透性的超声波。
超声介导的基因传递与微泡试剂提供了显著的安全优势超过其他方法的局部基因传递。
