School of Health, Iran University of Medical Sciences, Tehran 1449614525, Iran.
Int J Food Sci Nutr. 2010 Mar;61(2):182-91. doi: 10.3109/09637480903334171.
There is accumulating evidence that shows the metabolism of zinc and vitamin A are altered in diabetes mellitus type I (DMTI), thus the present study was conducted to evaluate the effects of combination of zinc and vitamin A supplementation on serum fasting blood sugar (FBS), insulin, apoprotein B and apoprotein A-I in patients with DMTI.
Forty-eight, 7-year-old to 20-year-old patients with at least 2 years of DMTI history, without any metabolic condition or medicine intake with insulin treatment, participated in a randomized double-blind clinical trial for 12 weeks. They were divided into zinc and vitamin A (VAZ)-supplemented (10 mg elemental zinc per day and one-half of a 25,000 IU vitamin A tablet every other day) and/or placebo groups after matching for sex, age and DMTI duration. Nutrient intake was estimated using 24 h recall and was analyzed by food processor program. Serum apoproteins B and A-I, FBS and insulin levels were determined at the beginning and end of the trial.
There was significant increase in apoprotein A-I (P < 0.0001) and a significant decrease in apoprotein B (P < 0.0001) and apoprotein B/apoprotein A-I ratio (P < 0.0001) at the end of the study compared with baseline values in the VAZ group but apoprotein A-I had a significant increase (P < 0.0001) and the apoprotein B/apoprotein A-I ratio had a significant decrease (P = 0.02) at the end of study in the VAZ group compared with the control group
It seems that combined zinc and vitamin A supplementation can improve serum apoprotein A-I, apoprotein B and the apoprotein B/apoprotein A-I ratio in patients with DMTI.
有越来越多的证据表明，Ⅰ型糖尿病（DMTI）患者的锌和维生素 A 代谢发生改变。因此，本研究旨在评估补充锌和维生素 A 对 DMTI 患者血清空腹血糖（FBS）、胰岛素、载脂蛋白 B 和载脂蛋白 A-I 的影响。
48 名年龄在 7 岁至 20 岁之间、患有 DMTI 至少 2 年且无任何代谢紊乱或药物摄入（包括胰岛素治疗）的患者参与了一项为期 12 周的随机双盲临床试验。根据性别、年龄和 DMTI 持续时间，将他们分为锌和维生素 A（VAZ）补充组（每天补充 10 毫克元素锌，每两天服用半片 25000IU 维生素 A 片剂）和/或安慰剂组。通过 24 小时回忆法估计营养素摄入量，并使用食品处理器程序进行分析。在试验开始和结束时，测定血清载脂蛋白 B 和 A-I、FBS 和胰岛素水平。
与基线值相比，VAZ 组在研究结束时载脂蛋白 A-I 显著增加（P<0.0001），载脂蛋白 B（P<0.0001）和载脂蛋白 B/载脂蛋白 A-I 比值（P<0.0001）显著降低，但 VAZ 组在研究结束时载脂蛋白 A-I 显著增加（P<0.0001），且载脂蛋白 B/载脂蛋白 A-I 比值显著降低（P=0.02）与对照组相比。
联合补充锌和维生素 A 似乎可以改善 DMTI 患者的血清载脂蛋白 A-I、载脂蛋白 B 和载脂蛋白 B/载脂蛋白 A-I 比值。
