Said Eman, Mousa Shrook, Fawzi May, Sabry Nirmeen A, Farid Samar
Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Department of Internal Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
J Adv Res. 2020 Jun 21;28:27-33. doi: 10.1016/j.jare.2020.06.013. eCollection 2021 Feb.
In type 2 diabetes mellitus (T2DM), hyperglycemia leads to oxidative insult. Vitamins A and E have antioxidant potentials and may help in managing diabetes. The combined effect of high-dose vitamin A plus E supplementation with and without zinc on T2DM, has never been examined. Thus, this study aimed to evaluate and compare the effect of high-dose vitamin A plus E supplementation (AE) versus high-dose vitamin A plus E with zinc (AEZ), on different diabetic parameters. Ninety-eight patients with T2DM were randomized to receive either: 50,000 IU vitamin A and 100 mg vitamin E (AE group, N = 36), an equivalent dose of vitamin A and E combined with 25 mg zinc (AEZ group, N = 35), or no supplements (control group, N = 27) for three months. Compared to control, AEZ group showed significant reductions in fasting blood glucose, 2 h postprandial blood glucose, and glycated hemoglobin (HbA1c) with significant increases in homeostasis model assessment of beta-cell function and difference value of fasting insulin. Two hair loss cases were recorded in both treated groups. Although vitamin A needs dose moderation, these results suggest that, high-dose vitamin A plus E supplementation combined with zinc may improve glycemic control, β-cell function, and insulin secretion in adults with T2DM.
在2型糖尿病（T2DM）中，高血糖会导致氧化损伤。维生素A和E具有抗氧化潜力，可能有助于控制糖尿病。高剂量维生素A加E联合补充（无论是否添加锌）对T2DM的综合影响从未被研究过。因此，本研究旨在评估和比较高剂量维生素A加E补充剂（AE）与高剂量维生素A加E联合锌（AEZ）对不同糖尿病参数的影响。98例T2DM患者被随机分为三组，分别接受：50,000国际单位维生素A和100毫克维生素E（AE组，N = 36）；等量的维生素A和E联合25毫克锌（AEZ组，N = 35）；或不补充任何物质（对照组，N = 27），为期三个月。与对照组相比，AEZ组的空腹血糖、餐后2小时血糖和糖化血红蛋白（HbA1c）显著降低，β细胞功能的稳态模型评估和空腹胰岛素差值显著增加。两个治疗组均记录到两例脱发病例。虽然维生素A需要适度剂量，但这些结果表明，高剂量维生素A加E联合锌补充剂可能改善成年T2DM患者的血糖控制、β细胞功能和胰岛素分泌。
