Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia.
Neuron. 2010 Jan 28;65(2):143-4. doi: 10.1016/j.neuron.2010.01.015.
Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density.
新型口服载体镁 3-氧代戊酸酯可提升大脑中的镁离子浓度，在为期 12-24 天的治疗期间可增强年轻和老年大鼠的认知能力，这在 Slutsky 等人发表于本期《神经元》的论文中有所概述。尽管镁离子和锌离子均可阻断 NMDA 受体通道，但通过增加海马 NR2B 表达和突触及密度，持续升高细胞外镁离子浓度可模拟持续的突触锌离子浓度。
