Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
Neuron. 2010 Jan 28;65(2):280-90. doi: 10.1016/j.neuron.2010.01.001.
Long-term storage of episodic memories is hypothesized to result from the off-line transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent cortical representation to emerge. However, off-line hippocampal-cortical interactions have not been demonstrated to be linked with long-term memory. Here, using functional magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations during rest following an associative encoding task are related to later associative memory performance. Our data show enhanced functional connectivity between the hippocampus and a portion of the lateral occipital complex (LO) during rest following a task with high subsequent memory compared to pretask baseline resting connectivity. This effect is not seen during rest following a task with poor subsequent memory. Furthermore, the magnitude of hippocampal-LO correlations during posttask rest predicts individual differences in later associative memory. These results demonstrate the importance of postexperience resting brain correlations for memory for recent experiences.
长时程情景记忆的储存被假设是离线信息从海马体转移到新皮层的结果，从而产生一个海马体独立的皮质代表。然而，离线的海马-皮层相互作用尚未被证明与长时记忆有关。在这里，我们使用功能磁共振成像，研究了在联想性编码任务后的休息期间，海马-皮层 BOLD 相关性是否与随后的联想记忆表现有关。我们的数据显示，与任务前基线休息时的连接性相比，在后续记忆高的任务后休息时，海马体和外侧枕叶复合体（LO）的一部分之间的功能连接性增强。在后续记忆差的任务后休息时，不会出现这种情况。此外，任务后休息时海马体与 LO 的相关性的幅度可以预测随后联想记忆的个体差异。这些结果表明，经历后休息时大脑相关性对最近经历的记忆很重要。
