翻开表观遗传书签的新篇章。
Turning the page on epigenetic bookmarks.
机构信息
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Dev Cell. 2010 Jan 19;18(1):4-5. doi: 10.1016/j.devcel.2010.01.004.
Abstract
Cells remember established patterns of gene expression through rounds of cell division despite dynamic changes in genomic chromatin structure. Two recent studies in Molecular Cell and Nature Medicine, broadly impacting on epigenetic gene regulation and disease, address how cells remember and suggest that both histone methyltransferases and locus specific DNA binding proteins can mark transcribed genes for reactivation after mitosis.
摘要
细胞在经历基因组染色质结构的动态变化时，通过多轮细胞分裂来记住既定的基因表达模式。最近在《分子细胞》和《自然医学》上发表的两项研究广泛影响了表观遗传基因调控和疾病，它们探讨了细胞如何记忆，并表明组蛋白甲基转移酶和特定基因座的 DNA 结合蛋白可以为有丝分裂后基因的重新激活做标记。
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