Johansen Kristen M, Johansen Jørgen
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, 3154 Molecular Biology Building, Ames, Iowa 50011, USA.
Chromosome Res. 2006;14(4):393-404. doi: 10.1007/s10577-006-1063-4.
The epigenetic phospho-serine 10 modification of histone H3 has been a puzzle due to its association with two apparently opposed chromatin states. It is found at elevated levels on the highly condensed, transcriptionally inactive mitotic chromosomes yet is also correlated with the more extended chromatin configuration of active genes, euchromatic interband regions, and activated heat shock puffs of Drosophila polytene chromosomes. In addition, phosphorylation of histone H3S10 is up-regulated on the hypertranscribed male X chromosome. Here we review the cellular effects of histone H3S10 phosphorylation and discuss a model for its involvement in regulating chromatin organization and heterochromatization that would be applicable to both interphase and mitotic chromosomes.
组蛋白H3的表观遗传磷酸化丝氨酸10修饰一直是个谜题，因为它与两种明显相反的染色质状态相关联。在高度浓缩、转录无活性的有丝分裂染色体上，其水平升高，但也与活性基因、常染色质间带区域以及果蝇多线染色体中活化的热休克疏松区更伸展的染色质构型相关。此外，在过度转录的雄性X染色体上，组蛋白H3S10的磷酸化上调。在这里，我们综述组蛋白H3S10磷酸化的细胞效应，并讨论其参与调节染色质组织和异染色质化的模型，该模型适用于间期和有丝分裂染色体。
