Stanford University School of Medicine, Stanford, CA 94305-5405, USA.
Am Heart J. 2010 Feb;159(2):292-300. doi: 10.1016/j.ahj.2009.11.004.
Obesity increases the risk of type 2 diabetes and coronary artery disease (CAD). Because all 3 conditions may reduce quality of life, the extent to which obesity, diabetes, and CAD independently affect quality of life is uncertain.
Patients with type 2 diabetes and documented CAD participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial at 45 clinical sites in the United States and Canada were studied in a cross-sectional analysis of baseline data. Quality of life was assessed with the Duke Activity Status Index, the energy/fatigue and health distress scales from the Medical Outcome Study, and overall self-rated health status.
Higher body mass index was significantly associated with worse scores on all 4 quality of life scales, even after adjustment for the severity of diabetes and CAD and other comorbid conditions. Use of insulin, angina, and current smoking were also associated with significantly lower quality of life on all 4 scales, independent of other factors.
Obesity is associated with significantly reduced quality of life in patients with diabetes and CAD, independent of comorbid conditions.
肥胖会增加 2 型糖尿病和冠状动脉疾病（CAD）的风险。由于所有 3 种情况都可能降低生活质量，因此肥胖、糖尿病和 CAD 独立影响生活质量的程度尚不确定。
在美国和加拿大的 45 个临床站点参与 Bypass Angioplasty Revascularization Investigation 2 Diabetes 试验的 2 型糖尿病和有记录的 CAD 患者在横断面分析基线数据中进行了研究。使用杜克活动状态指数、医疗结果研究的能量/疲劳和健康困扰量表以及整体自我评估健康状况来评估生活质量。
即使在调整了糖尿病和 CAD 的严重程度以及其他合并症后，较高的体重指数与所有 4 种生活质量量表的评分明显更差相关。使用胰岛素、心绞痛和当前吸烟也与所有 4 种量表的生活质量明显降低相关，独立于其他因素。
肥胖与患有糖尿病和 CAD 的患者的生活质量明显降低相关，与合并症无关。
