School of Dentistry, Pusan National University, Yangsan, South Korea.
Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Front Endocrinol (Lausanne). 2022 Oct 24;13:999455. doi: 10.3389/fendo.2022.999455. eCollection 2022.
A previous 2014 meta-analysis reported a positive association between obesity and periodontitis. It was considered necessary to update the recently published papers and to analyse subgroups on important clinical variables that could affect the association between obesity and periodontitis. Therefore, we updated the latest studies and attempted to derive more refined results.
All observational studies were eligible for inclusion. The Newcastle-Ottawa scale was used to qualitatively evaluate the risk of bias. Subgroup analyses were conducted for patients aged 18-34, 35-54, and 55+ years and the countries (European countries, USA, Brazil, Japan, Korea, and other Asian countries).
Thirty-seven full-text articles were included. Obesity conferred increased odds of periodontal disease with an odds ratio (1.35, 95% CI: 1.05-1.75). In the subgroup analysis by age, the odds ratio was the highest in the 18-34 years group (2.21, 95% CI: 1.26-3.89). In the subgroup analysis by country, European countries had the highest odds ratio (2.46, 95% CI: 1.11-5.46).
Despite the differences in degree, a positive association between obesity and periodontitis was found regardless of country or age. Therefore, medical professionals should try to prevent periodontitis by controlling patient weights, and more studies should be conducted to determine the association between obesity and oral health.
https://www.crd.york.ac.uk/prospero/, identifier CRD42022301343.
2014 年的一项荟萃分析报告称，肥胖与牙周炎之间存在正相关关系。考虑到有必要更新最近发表的论文，并分析可能影响肥胖与牙周炎之间关联的重要临床变量亚组，因此，我们更新了最新的研究，并试图得出更精确的结果。
所有观察性研究都符合纳入标准。使用纽卡斯尔-渥太华量表对偏倚风险进行定性评估。进行了亚组分析，亚组分析对象为年龄在 18-34 岁、35-54 岁和 55 岁以上的患者，以及来自欧洲国家、美国、巴西、日本、韩国和其他亚洲国家的患者。
共纳入 37 篇全文文章。肥胖使牙周病的发病几率增加，比值比（odds ratio，OR）为 1.35（95%置信区间：1.05-1.75）。在按年龄进行的亚组分析中，18-34 岁组的比值比最高（OR 为 2.21，95%置信区间：1.26-3.89）。在按国家进行的亚组分析中，欧洲国家的比值比最高（OR 为 2.46，95%置信区间：1.11-5.46）。
尽管程度不同，但无论国家或年龄如何，肥胖与牙周炎之间都存在正相关关系。因此，医务人员应尝试通过控制患者体重来预防牙周炎，并且应该进行更多的研究来确定肥胖与口腔健康之间的关系。
https://www.crd.york.ac.uk/prospero/，标识符 CRD42022301343。
