产前暴露于烟草与精神分裂症风险：回顾性流行病学研究。
Prenatal exposure to tobacco and risk for schizophrenia: a retrospective epidemiological study.
机构信息
Department of Psychiatry, Rouen University Hospital, Rouen 76031, France.
出版信息
Compr Psychiatry. 2010 Mar-Apr;51(2):106-9. doi: 10.1016/j.comppsych.2009.03.012. Epub 2009 May 5.
INTRODUCTION
In animal studies, long-term prenatal nicotinic exposure alters the development of dopaminergic neurons. To determine whether prenatal smoking exposure was associated with schizophrenia, using a retrospective design study, we compared the prevalence of tobacco use during pregnancy in mothers of subjects with and without schizophrenia.
METHODS
One hundred patients with schizophrenia, 100 nonschizophrenic-matched subjects, and their respective mothers were interviewed. The prevalence of smoking was measured in these individuals as well as in their respective mothers during the pregnancy.
RESULTS
Patients with schizophrenia smoked more often compared with controls (73% vs 57%). In contrast, the prevalence of smoking during pregnancy did not differ between the groups of mothers. Indeed, the amount of tobacco used was significantly lower in mothers of patients with schizophrenia vs mothers of nonpsychotic subjects.
CONCLUSION
This study did not show any association between prenatal tobacco exposure and further development of schizophrenia.
简介
在动物研究中，长期产前烟碱暴露会改变多巴胺能神经元的发育。为了确定产前吸烟暴露是否与精神分裂症有关，我们采用回顾性设计研究，比较了有和无精神分裂症的受试者的母亲在怀孕期间吸烟的流行率。
方法
对 100 例精神分裂症患者、100 例非精神分裂症匹配对照者及其各自的母亲进行了访谈。在这些个体以及他们各自的母亲怀孕期间，测量了吸烟的流行率。
结果
与对照组相比，精神分裂症患者吸烟更为常见（73% vs 57%）。相比之下，两组母亲怀孕期间吸烟的流行率没有差异。实际上，精神分裂症患者母亲使用的烟草量明显低于非精神病患者母亲。
结论
本研究未显示产前烟草暴露与精神分裂症的进一步发展之间存在任何关联。
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