Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, United States.
Psychiatry Res. 2010 Mar 30;181(3):174-82. doi: 10.1016/j.pscychresns.2009.11.003. Epub 2010 Feb 12.
Functional magnetic resonance imaging (fMRI) studies of early abstinence cocaine users offer information about the state of the brain when most cocaine users seek treatment. This study examined the relationship between pretreatment brain function and subsequent treatment response in 19 treatment-seeking early abstinence cocaine-dependent (CD) subjects. These subjects and 14 non-drug-using control subjects underwent fMRI while performing a working memory task with three levels of difficulty. CD subjects were then randomized to treatment studies. Results showed CD subjects had significantly lower (random effects, corrected for multiple comparisons) brain activation in caudate, putamen, cingulate gyrus, middle and superior frontal gyri, inferior frontal gyrus pars triangularis and pars opercularis, precentral gyrus, and thalamus compared with non-drug-using controls. Within CD subjects, thalamic activation significantly correlated with treatment response. This study shows CD subjects in early abstinence have alterations of brain function in frontal, striatal, and thalamic brain regions known to be part of a circuit associated with motor control, reward, and cognition. Subjects with pretreatment thalamic deactivation showed the poorest treatment response, possibly related to thalamic involvement in mesocortical and mesolimbic dopamine projections.
功能磁共振成像（fMRI）研究早期戒断可卡因使用者提供了关于大多数可卡因使用者寻求治疗时大脑状态的信息。这项研究调查了 19 名寻求治疗的早期戒断可卡因依赖（CD）受试者的预处理大脑功能与随后的治疗反应之间的关系。这些受试者和 14 名非药物使用对照受试者在执行具有三个难度级别的工作记忆任务时接受了 fMRI。然后，CD 受试者被随机分配到治疗研究中。结果表明，与非药物使用对照组相比，CD 受试者的尾状核、壳核、扣带回、中额和上额回、下额回三角部和眶部、中央前回和丘脑的大脑激活明显降低（随机效应，经多重比较校正）。在 CD 受试者中，丘脑的激活与治疗反应显著相关。这项研究表明，早期戒断的 CD 受试者的大脑功能在前额叶、纹状体和丘脑区域发生改变，这些区域已知是与运动控制、奖励和认知相关的回路的一部分。预处理时丘脑失活的受试者治疗反应最差，可能与丘脑参与中脑皮质和中脑边缘多巴胺投射有关。
