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储存红细胞经γ射线照射后的电学行为以及α-硫辛酸作为辐射防护剂的作用。

Electrical behavior of stored erythrocytes after exposure to gamma radiation and the role of alpha-lipoic acid as radioprotector.

作者信息

Selim Nabila S, Desouky Omar S, Elbakrawy Eman M, Rezk Rezk A

机构信息

Biophysics Laboratory, Radiation Physics Department, National Center for Radiation Research and Technology, AEA, POB 29 Madinat Nasr, Cairo, Egypt.

出版信息

Appl Radiat Isot. 2010 Jun;68(6):1018-24. doi: 10.1016/j.apradiso.2010.01.020. Epub 2010 Jan 25.

DOI:10.1016/j.apradiso.2010.01.020
PMID:20153208
Abstract

The effects of gamma rays (25, 50 and 100 Gy) on stored erythrocytes were studied by measuring their dielectric properties and observing their morphology under scanning electron microscopy. Alpha lipoic acid (a potent natural antioxidant) was introduced prior to irradiation for radioprotection. It can be concluded that the dose level of 25 Gy can be considered a safe sterile dose; however, irradiation doses of 50 and 100 Gy should be applied with the addition of alpha-acid to preserve the cell viability.

摘要

通过测量储存红细胞的介电特性并在扫描电子显微镜下观察其形态,研究了γ射线(25、50和100戈瑞)对储存红细胞的影响。在辐照前引入α硫辛酸(一种有效的天然抗氧化剂)以进行辐射防护。可以得出结论,25戈瑞的剂量水平可被视为安全的灭菌剂量;然而,50和100戈瑞的辐照剂量应在添加α酸的情况下使用,以保持细胞活力。

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