Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Int J Infect Dis. 2010 Sep;14 Suppl 3:e36-40. doi: 10.1016/j.ijid.2009.10.005. Epub 2010 Feb 12.
The clinical impact of seasonal influenza is understudied in tropical countries. The aim of this study was to describe the clinical features and seasonal pattern of influenza in children hospitalized in Malaysia, and to identify predictors of severe disease.
Children hospitalized with community-acquired, laboratory-confirmed influenza at a teaching hospital in Kuala Lumpur, Malaysia during 2002-2007 were identified retrospectively. Clinical data were collected, and predictors of severe disease were identified by multivariate logistic regression. All influenza cases from 1982 to 2007 were also analyzed for seasonal patterns.
A total of 132 children were included in the study, 48 (36.4%) of whom had underlying medical conditions. The mean age was 2.5 years and 116 (87.9%) were <5 years old. The most common presenting features were fever or history of fever, cough, rhinitis, vomiting, and pharyngitis. Severe influenza was seen in 16 patients (12.1%; nine previously healthy), including 12 (9.1%; eight previously healthy) requiring intensive care. There were three (2.3%) deaths. Severe disease was associated with age <12 months, female sex, and absence of rhinitis on admission. Influenza was seen year-round, with peaks in November-January and May-July.
Seasonal influenza has a considerable impact on children hospitalized in Malaysia, in both the healthy and those with underlying medical conditions.
在热带国家，季节性流感的临床影响研究不足。本研究旨在描述马来西亚住院儿童中流感的临床特征和季节性模式，并确定重症疾病的预测因素。
回顾性确定了在马来西亚吉隆坡一所教学医院因社区获得性、实验室确诊流感住院的儿童。收集临床数据，并通过多变量逻辑回归确定重症疾病的预测因素。还分析了 1982 年至 2007 年所有流感病例的季节性模式。
共纳入 132 例儿童，其中 48 例（36.4%）有基础疾病。平均年龄为 2.5 岁，116 例（87.9%）<5 岁。最常见的表现特征是发热或发热史、咳嗽、鼻炎、呕吐和咽炎。16 例（12.1%；9 例既往健康）患儿出现严重流感，包括 12 例（9.1%；8 例既往健康）需要重症监护。有 3 例（2.3%）死亡。重症疾病与<12 个月、女性和入院时无鼻炎有关。流感全年可见，11 月至 1 月和 5 月至 7 月出现高峰。
季节性流感对马来西亚住院儿童，包括健康儿童和有基础疾病的儿童，都有相当大的影响。
