Boehm G, Teichmann B, Jung K
Department of Pediatrics, University of Leipzig, FRG.
Biol Neonate. 1991;59(1):1-4. doi: 10.1159/000243315.
The urea-synthesizing capacity of the liver was studied in 20 healthy preterm infants during the first month of life. The urea-synthesizing capacity was estimated by the ratio of 15N abundances of ammonia and urea in the 6-hour urine after administration of 3 mg 15N-labelled ammonium chloride/kg body weight. The ratio increases with increasing protein intakes from the 2nd to the 3rd week of life. On protein intakes of more than 3 g/kg/protein day from the 3rd week to the end of the 2nd month of life, the ratio decreases suggesting a maturation of the urea cycle during the first weeks of life.
对20名健康早产婴儿出生后第一个月的肝脏尿素合成能力进行了研究。通过给予3mg 15N标记氯化铵/kg体重后6小时尿液中氨和尿素的15N丰度比来估算尿素合成能力。从出生后第2周到第3周，该比值随着蛋白质摄入量的增加而升高。从出生后第3周到第2个月末，当蛋白质摄入量超过3g/kg/天蛋白质时，该比值下降，提示在出生后的最初几周尿素循环逐渐成熟。
