无支架细胞递送在再生医学中的应用。

Scaffold-free cell delivery for use in regenerative medicine.

机构信息

Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland.

出版信息

Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):753-64. doi: 10.1016/j.addr.2010.02.003. Epub 2010 Feb 11.

DOI:10.1016/j.addr.2010.02.003

PMID:20153387

Abstract

The development of cell-based therapies for diseased tissues is one of the most promising research directions in regenerative medicine. Cell-delivery methods are an essential part of cell therapy concepts. Therapies with the potential to become clinical routine will only be possible if these methods ensure efficient engraftment and therapeutically-relevant number of cells survive. Here we provide an overview of three different scaffold-free cell-delivery concepts: (i) single cell delivery, (ii) cell sheet engineering and (iii) microtissue technology.

摘要

用于病变组织的基于细胞的疗法的发展是再生医学中最有前途的研究方向之一。细胞输送方法是细胞治疗概念的重要组成部分。只有这些方法确保有效的植入和治疗相关数量的细胞存活，具有成为临床常规的潜力的疗法才有可能。在这里，我们提供了三种不同的无支架细胞输送概念的概述：（i）单细胞输送，（ii）细胞片工程和（iii）微组织技术。