Dermatología II, Hospital Universitario Central de Asturias, Oviedo, Spain.
Cytokine. 2010 May;50(2):114-6. doi: 10.1016/j.cyto.2010.01.006. Epub 2010 Feb 12.
Inflammation plays a major role in psoriasis (Ps). The variation at several genes that encode components of the inflammatory pathways have been linked to the risk for Ps. Our objective was to examine the association between Ps and three polymorphisms at the chemokine receptors CCR5 and CCR2.
A total of 382 Ps patients and 500 healthy controls from Spain were genotyped for the CCR5-32bp deletion (DeltaCCR5), the rs1799988 (CCR5 promoter), and the CCR2-I64V (rs1799864) polymorphisms.
Allele and genotype frequencies did not differ between patients and controls for any of the three polymorphisms. However, the frequency of the CCR2-64I carriers was significantly higher in the patients who developed arthritis (n=81) compared to patients without arthritis (p=0.0007).
Our work suggests that the genetic variation at the CCR2/CCR5 genes did not contribute to the risk for Ps, but CCR2 polymorphisms could modulate the risk for arthritis in patients with psoriasis.
炎症在银屑病（Ps）中起主要作用。编码炎症途径组成部分的几个基因的变异与 Ps 的风险相关。我们的目的是研究趋化因子受体 CCR5 和 CCR2 上的三个多态性与 Ps 之间的关联。
对来自西班牙的 382 名 Ps 患者和 500 名健康对照者进行 CCR5-32bp 缺失（DeltaCCR5）、rs1799988（CCR5 启动子）和 CCR2-I64V（rs1799864）多态性的基因分型。
在三个多态性中，患者和对照组之间的等位基因和基因型频率没有差异。然而，在发生关节炎（n=81）的患者中，CCR2-64I 携带者的频率明显高于无关节炎的患者（p=0.0007）。
我们的工作表明，CCR2/CCR5 基因的遗传变异并未增加患银屑病的风险，但 CCR2 多态性可能会调节银屑病患者关节炎的风险。
