School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Liggins Institute, University of Auckland, and the National Research Centre for Growth and Development, Auckland, New Zealand.
Fertil Steril. 2010 Sep;94(4):1544-1547. doi: 10.1016/j.fertnstert.2009.12.060. Epub 2010 Feb 13.
This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimüllerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function.
本前瞻性研究旨在确定正常妊娠期间母体循环雄激素水平对卵巢功能的影响，通过在青春期的 244 名女性后代的早卵泡期抗缪勒管激素 (AMH) 水平、抑制素 B 水平和窦卵泡计数 (AFC) 来评估。母体循环中的总睾酮水平在 18 周妊娠时与女性青春期后代的早卵泡期循环 AMH 水平呈统计学显著相关，但在母体雄激素在 18 或 34 周妊娠时与青春期卵巢功能的标志物之间没有发现其他统计学显著相关性。
