Shah Rachana
Division of Pediatric Endocrinology, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, 3615 Civic Center Blvd, 802F Philadelphia, PA 19104, USA.
Children (Basel). 2019 Jul 31;6(8):89. doi: 10.3390/children6080089.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, affecting 6-10% of reproductive age women and influences the reproductive, metabolic, dermatologic, and psychiatric health of affected girls and women. Despite its prevalence, the pathogenesis of the disease is largely unknown, and treatment options are limited. Thus, PCOS has been a ripe area for research in recent years, and novel etiologic pathways, diagnostic parameters, and treatment options are being explored. This review focuses on recent data suggesting pathogenic and therapeutic considerations, as well as the psychiatric and metabolic sequelae of PCOS.
多囊卵巢综合征(PCOS)是一种常见的内分泌紊乱疾病,影响6%至10%的育龄妇女,并对受影响的女孩和妇女的生殖、代谢、皮肤和精神健康产生影响。尽管其发病率很高,但该疾病的发病机制在很大程度上尚不清楚,治疗选择也有限。因此,PCOS近年来一直是一个成熟的研究领域,新的病因途径、诊断参数和治疗选择正在被探索。本综述重点关注近期数据,这些数据提示了PCOS的发病机制和治疗考量,以及其精神和代谢后遗症。