Aresu L, Zanatta R, Luciani L, Trez D, Castagnaro M
Universita degli Studi di Padova, Dipartimento di Sanità Pubblica, Patologia Comparata e Igiene Veterinaria, Facoltà di Medicina Veterinaria, Padova, Italy.
J Comp Pathol. 2010 Aug-Oct;143(2-3):190-4. doi: 10.1016/j.jcpa.2009.12.016. Epub 2010 Feb 13.
A case of renal disease in a dog resembling human focal segmental glomerulosclerosis is presented. A kidney biopsy from this animal showed focal glomerular sclerosis, with variable distribution, affecting the perihilar and peripheral segments of the glomerular tuft. Non-sclerotic glomeruli were markedly enlarged. Interstitial fibrosis in association with tubular atrophy affected approximately 20% of the area of the biopsy. Immunofluorescence labelling showed immunoglobulin M deposits entrapped in segmental sclerotic areas and ultrastructural examination revealed segmental sclerosis and obliteration of capillaries, vacuolation of podocytes and diffuse effacement of foot processes. The dog was humanely destroyed 1 month later. At necropsy examination there was severe end-stage kidney disease with interstitial fibrosis involving more than 60% of the renal tissue. The clinical course and the microscopical, immunofluorescence and ultrastructural findings in this case have similarity to focal segmental glomerulosclerosis in man.
本文报告了一例犬类肾病，其症状与人局灶节段性肾小球硬化症相似。对该动物进行的肾活检显示局灶性肾小球硬化，分布不一，影响肾小球毛细血管袢的肾门周围和外周部分。未硬化的肾小球明显增大。伴有肾小管萎缩的间质纤维化累及活检区域约20%的面积。免疫荧光标记显示免疫球蛋白M沉积于节段性硬化区域，超微结构检查显示节段性硬化和毛细血管闭塞、足细胞空泡化以及足突弥漫性消失。1个月后该犬被人道处死。尸检发现存在严重的终末期肾病，间质纤维化累及超过60%的肾组织。该病例的临床病程以及显微镜、免疫荧光和超微结构检查结果与人局灶节段性肾小球硬化症相似。
