Amorim I, Lopes C C, Faustino A M R, Pereira P Dias
ICBAS-UP, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Largo Prof. Abel Salazar, 2, 4099-003 Porto, Portugal.
J Comp Pathol. 2010 Jul;143(1):39-44. doi: 10.1016/j.jcpa.2009.12.019. Epub 2010 Feb 13.
Caveolins are the major structural proteins of caveolae and play a role in tumour surveillance. The expression of caveolin-1 (Cav-1) was investigated immunohistochemically in samples of normal canine mammary tissue (n=5), benign (n=23) and malignant (n=45) mammary tumours, tumour emboli (n=10) and metastatic lesions (n=10). Cav-1 was not expressed by normal luminal epithelium, but was consistently expressed by normal myoepithelial cells. There was no epithelial expression of Cav-1 by the benign mammary lesions, but the molecule was detected in 35.6% of the malignant lesions, 80% of the tumour emboli and in 40% of the metastatic lesions. These findings link increased expression of Cav-1 to neoplastic transformation and suggest that Cav-1 expression is associated with more malignant canine mammary tumours and their vascular invasion and regional lymph node metastasis.
小窝蛋白是小窝的主要结构蛋白，在肿瘤监测中发挥作用。采用免疫组织化学方法研究了正常犬乳腺组织样本（n=5）、良性（n=23）和恶性（n=45）乳腺肿瘤、肿瘤栓子（n=10）和转移灶（n=10）中小窝蛋白-1（Cav-1）的表达情况。正常管腔上皮不表达Cav-1，但正常肌上皮细胞持续表达。良性乳腺病变中Cav-1无上皮表达，但在35.6%的恶性病变、80%的肿瘤栓子和40%的转移灶中检测到该分子。这些发现将Cav-1表达增加与肿瘤转化联系起来，并表明Cav-1表达与更具恶性的犬乳腺肿瘤及其血管侵袭和区域淋巴结转移有关。
