InSPIRES-Department of Psychiatry, New York University School of Medicine, New York, NY, United States.
Schizophr Res. 2010 May;118(1-3):76-80. doi: 10.1016/j.schres.2010.01.013. Epub 2010 Feb 13.
Schizophrenia has been linked to advanced paternal age, but the explanation is unknown. We questioned whether the incidence of schizophrenia would be related to male reproductive capacity, as reflected in the time taken to conceive. We measured the incidence of schizophrenia in relation to time to conception in a sub-group of 12,269 in the Jerusalem cohort whose mothers, interviewed post-partum, reported that the pregnancy had been intended. Compared with those conceived in less than 3 months, the unadjusted relative risks (RR) of schizophrenia associated with conception-waits of 3-5, 6-11 and 12+ months were 1.10 (95% confidence interval, 0.62-1.94), 1.41 (0.79-2.52) and 1.88 (1.05-3.37) with p for trend=0.035. This trend was attenuated somewhat by adjusting for paternal age, and was observed more strongly in offspring of fathers aged 30+ (p=.010). These findings suggest that factors associated with fecundability, either male or female, may contribute to the risk of schizophrenia.
精神分裂症与父亲年龄较大有关，但原因尚不清楚。我们质疑精神分裂症的发病率是否与男性的生殖能力有关，而生殖能力反映在受孕所需的时间上。我们在耶路撒冷队列中，对 12269 名母亲进行了产后访谈，其中有部分母亲报告说怀孕是有意为之，我们在这部分人当中，测量了精神分裂症的发病率与受孕所需时间之间的关系。与受孕时间不到 3 个月的人相比，受孕时间为 3-5 个月、6-11 个月和 12 个月以上的人，其未调整的相对风险（RR）分别为 1.10（95%置信区间，0.62-1.94）、1.41（0.79-2.52）和 1.88（1.05-3.37），趋势检验的 P 值为 0.035。这种趋势在调整了父亲年龄后略有减弱，在父亲年龄 30 岁以上的后代中观察到的趋势更为明显（P=.010）。这些发现表明，与生育能力相关的因素（无论是男性还是女性），可能会增加精神分裂症的风险。
