Tsuchiya Kenji J, Takagai Shu, Kawai Masayoshi, Matsumoto Hideo, Nakamura Kazuhiko, Minabe Yoshio, Mori Norio, Takei Nori
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Schizophr Res. 2005 Jul 15;76(2-3):337-42. doi: 10.1016/j.schres.2005.03.004. Epub 2005 Apr 21.
Advanced paternal age at birth as a risk for schizophrenia in the adult offspring has been reported in previous studies exclusively conducted in Western countries and Israel. The question has arisen whether this finding could be replicated in countries with socially and culturally different attitudes toward marriage, including factors such as age at marriage. To address this question, we conducted a case-control study of a Japanese population.
The subjects were representative inpatients with a DSM-IV diagnosis of schizophrenia. Unrelated healthy volunteers were recruited as control subjects. This study was conducted as one of a series of the projects by use of "The Mother and Child Health Handbooks (MCHHs)," from which information on parental characteristics around the time of birth, including parental ages at birth, had been extracted and recorded on computer.
Ninety-nine subjects with schizophrenia and 381 healthy control subjects enrolled for the study. Advanced paternal, but not maternal, age was associated with an elevated risk for schizophrenia. Reproducibility of the association across different cultures is suggestive of a causal link.
先前仅在西方国家和以色列开展的研究报告称，父亲生育时年龄较大是成年子女患精神分裂症的一个风险因素。对于婚姻有着不同社会文化态度的国家，包括结婚年龄等因素，这一发现是否能够得到重复，这一问题由此产生。为解决这一问题，我们对日本人群开展了一项病例对照研究。
研究对象为符合《精神疾病诊断与统计手册》第四版（DSM-IV）精神分裂症诊断标准的有代表性的住院患者。招募无血缘关系的健康志愿者作为对照对象。本研究是一系列项目之一，通过使用“母子健康手册（MCHHs）”开展，从中提取了出生前后父母特征信息，包括父母的生育年龄，并记录在计算机上。
99名精神分裂症患者和381名健康对照对象纳入研究。父亲生育时年龄较大而非母亲生育时年龄较大与精神分裂症风险升高相关。该关联在不同文化中的可重复性提示存在因果联系。
