New York University Fertility Center, Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10015, USA.
Lancet Oncol. 2010 May;11(5):490-8. doi: 10.1016/S1470-2045(09)70317-1. Epub 2010 Feb 12.
Annually, more than 50,000 cancer diagnoses are made in the USA in patients under the age of 35 years. Despite this staggering statistic, medical advancements have substantially improved survival rates. Thus, for both male and female patients with cancer, quality-of-life issues, such as fertility preservation and parenthood, have become an essential component of treatment. Unfortunately, many of the treatments to eradicate malignant processes can also compromise reproductive function. In these cases, fertility preservation should be discussed and initiated with early treatment planning, to allow the best chance for future parenthood, when appropriate. The effects of cancer and cancer treatments on fertility and future parenthood, including health risks for patients, their gametes, and offspring are discussed.
每年，美国有超过 5 万名 35 岁以下的患者被诊断出患有癌症。尽管这一统计数据令人震惊，但医学的进步极大地提高了生存率。因此，对于患有癌症的男性和女性患者来说，生育力保存和为人父母等生活质量问题已成为治疗的重要组成部分。不幸的是，许多消除恶性肿瘤的治疗方法也会损害生殖功能。在这种情况下，应该在早期治疗计划中讨论并开始进行生育力保存，以便在适当的时候为未来的育儿提供最佳机会。本文讨论了癌症和癌症治疗对生育能力和未来育儿的影响，包括患者、其配子和后代的健康风险。
