School of Biological Sciences, Illinois State University, Normal, IL 61790-4120, USA.
J Exp Biol. 2010 Mar 1;213(5):661-71. doi: 10.1242/jeb.038315.
Reptiles are ectothermic amniotes, providing the key link between ectothermic anamniotic fishes and amphibians, and endothermic amniotic birds and mammals. A greater understanding of reptilian immunity will provide important insights into the evolutionary history of vertebrate immunity as well as the growing field of eco-immunology. Like mammals, reptile immunity is complex and involves innate, cell-mediated and humoral compartments but, overall, there is considerably less known about immune function in reptiles. We review the current literature on each branch of the reptilian immune system, placing this information in context to other vertebrates. Further, we identify key areas that are prime for research as well as areas that are lagging because of lack of reagents in non-model systems.
爬行动物是变温羊膜动物，为变温无羊膜鱼类和两栖动物与恒温羊膜鸟类和哺乳动物之间提供了关键联系。对爬行动物免疫的进一步了解将为脊椎动物免疫的进化历史以及日益发展的生态免疫学领域提供重要的见解。与哺乳动物一样，爬行动物的免疫是复杂的，涉及先天、细胞介导和体液成分，但总的来说，人们对爬行动物的免疫功能知之甚少。我们回顾了爬行动物免疫系统各个分支的现有文献，将这些信息置于与其他脊椎动物的背景下。此外，我们确定了研究的重点领域以及由于非模型系统缺乏试剂而滞后的领域。
