Tamei Noriko, Ogawa Tetsuya, Ishida Hideki, Ando Yoshitaka, Nitta Kosaku
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo.
Intern Med. 2010;49(4):299-305. doi: 10.2169/internalmedicine.49.2905. Epub 2010 Feb 15.
High molecular weight adiponectin (HMW ADPN) plays an important role in the regulation of insulin resistance and atherogenic processes. However, the role of HMW ADPN remains to be determined in hemodialysis (HD) patients.
We measured serum HMW ADPN in 49 HD patients (age: 62.4+/-12.0 years, time on HD: 8.4+/-6.4 years, male/female=30/19), and examined the association between HMW ADPN and visceral fat area (VFA) estimated by abdominal CT scans.
Serum HMW ADPN concentrations were weakly and inversely correlated with serum TG (r=-0.271, p=0.0598), but significantly and positively correlated with HDL cholesterol (r=0.392, p=0.0050). Serum HMW ADPN levels were positively correlated with BMI (r=0.472, p=0.0084) in male patients, and the HMW ADPN levels were positively correlated with serum levels of HDL cholesterol (r=0.514, p=0.0243) and TG (r=0.605, p=0.0061).The regression coefficient between VFA and HMW ADPN was -0.491 (p<0.003). Multiple stepwise regression analyses showed that VFA was the most significant and independent determinant of serum HMW ADPN concentration.
These findings suggest that HMW ADPN may be inversely associated with visceral fat accumulation in HD patients.
高分子量脂联素（HMW ADPN）在胰岛素抵抗和动脉粥样硬化形成过程的调节中发挥重要作用。然而，HMW ADPN在血液透析（HD）患者中的作用仍有待确定。
我们测定了49例HD患者（年龄：62.4±12.0岁，HD治疗时间：8.4±6.4年，男/女 = 30/19）的血清HMW ADPN，并通过腹部CT扫描检查了HMW ADPN与内脏脂肪面积（VFA）之间的关联。
血清HMW ADPN浓度与血清TG呈弱负相关（r = -0.271，p = 0.0598），但与高密度脂蛋白胆固醇呈显著正相关（r = 0.392，p = 0.0050）。男性患者血清HMW ADPN水平与BMI呈正相关（r = 0.472，p = 0.0084），且HMW ADPN水平与血清高密度脂蛋白胆固醇水平（r = 0.514，p = 0.0243）和TG（r = 0.605，p = 0.0061）呈正相关。VFA与HMW ADPN之间的回归系数为-0.491（p < 0.003）。多元逐步回归分析表明，VFA是血清HMW ADPN浓度最显著且独立的决定因素。
这些发现表明，HMW ADPN可能与HD患者内脏脂肪堆积呈负相关。
