Center for Infection and Immunity Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Cell Mol Immunol. 2010 Mar;7(2):100-3. doi: 10.1038/cmi.2009.119. Epub 2010 Feb 15.
As a testament to the importance of CD24, researchers with diverse interests, including adaptive immunity, inflammation, autoimmune diseases and cancer, have encountered CD24. CD24 is overexpressed in many cancers and appears oncogenic. In the adaptive immune response, CD24 is a redundant costimulatory molecule in costimulation-rich lymphoid organs but is essential in selected target organs tested, such as brain and skin. More recent studies suggest it may have a role in discriminating danger and pathogen-associated molecular patterns by dendritic cells. The biology of CD24 is intriguing but poorly understood. Here we summarize the major findings associated with CD24 to stimulate new ideas for further research that may reveal the underlying link among the diverse processes mediated by CD24.
作为 CD24 重要性的证明，包括适应性免疫、炎症、自身免疫性疾病和癌症在内的不同领域的研究人员都遇到过 CD24。CD24 在许多癌症中过度表达，表现出致癌性。在适应性免疫反应中，CD24 是富含共刺激分子的淋巴器官中冗余的共刺激分子，但在经过测试的特定靶器官中是必需的，如大脑和皮肤。最近的研究表明，它可能在树突状细胞区分危险和病原体相关分子模式方面发挥作用。CD24 的生物学很有趣，但了解甚少。在这里，我们总结了与 CD24 相关的主要发现，以激发新的研究思路，这些研究可能揭示 CD24 介导的不同过程之间的潜在联系。
