Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, NY, USA.
Cancer Causes Control. 2010 Jun;21(6):871-7. doi: 10.1007/s10552-010-9514-9. Epub 2010 Feb 13.
Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer.
The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days) x (exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders.
Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06-1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HR(highest tertile) = 1.21; 95% CI = 0.99-1.47) and lung (HR(middle tertile) = 1.45; 95% CI = 0.95-2.22) and leukemia (HR(middle tertile) = 2.38; 95% CI = 1.35-4.21) and non-Hodgkin's lymphoma (HR(middle tertile) = 1.94; 95% CI = 1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant.
We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.
特丁磷是美国第四大常用有机磷杀虫剂（OP）。尽管非砷杀虫剂，包括 OP，在流行病学研究中与癌症过量有关，但特丁磷尚未在啮齿动物中表现出致癌性。我们研究了特丁磷使用与癌症发病率之间的关系。
农业健康研究是一项针对来自爱荷华州和北卡罗来纳州的 57310 名持牌农药施药者的前瞻性队列研究。通过自我管理问卷获得了关于 50 种农药（包括特丁磷）和潜在混杂因素的详细信息。特丁磷强度加权终生暴露天数定义为（终生暴露天数）x（暴露强度评分）。病例包括 2005 年 12 月 31 日之前登记和 2005 年 12 月 31 日之间诊断出的所有首次原发性癌症。使用 Cox 比例风险模型计算风险比（HR）和 95%置信区间，并调整潜在混杂因素。
特丁磷使用者的总体癌症风险略有增加[HR 1.21（1.06-1.37）]。特丁磷使用与前列腺癌（HR（最高三分位）= 1.21；95%CI = 0.99-1.47）、肺癌（HR（中间三分位）= 1.45；95%CI = 0.95-2.22）和白血病（HR（中间三分位）= 2.38；95%CI = 1.35-4.21）和非霍奇金淋巴瘤（HR（中间三分位）= 1.94；95%CI = 1.16-3.22）之间存在提示性关联，尽管暴露-反应梯度非单调，且趋势 p 值无统计学意义。
我们发现职业性特丁磷使用与几个癌症部位之间存在提示性关联。然而，由于缺乏特丁磷致癌作用的现有实验和流行病学证据，对这些结果的谨慎解释是必要的。
