Francisco Luiza Flavia Veiga, da Silva Rogério Nunes, Oliveira Marco Antônio, Dos Santos Neto Martins Fideles, Gonçalves Iara Zapparoli, Marques Márcia M C, Silveira Henrique C S
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil.
Postgraduate Program in Environment and Health, University of Cuiabá, Cuiabá 78008-000, MT, Brazil.
Cancers (Basel). 2023 May 4;15(9):2600. doi: 10.3390/cancers15092600.
Non-Hodgkin lymphoma (NHL) is a heterogeneous group with different types of diseases. It remains unclear as to what has led to an increase in incidences of NHL, however, chemical substance exposure is known to be one of the risk factors for the disease. Therefore, we performed a systematic review and meta-analysis including case-control, cohort, and cross-sectional observational epidemiological studies to verify the association between occupational exposure to carcinogens and NHL risk. Articles between the years 2000 and 2020 were collected. Two different reviewers performed a blind selection of the studies using the Rayyan QCRI web app. Post-completion, the selected articles were extracted and analyzed via the RedCap platform. Our review resulted in 2719 articles, of which 51 were included in the meta-analysis, resulting in an overall OR of 1.27 (95% CI 1.04-1.55). Furthermore, it was observed that the main occupation associated with the increased risk of NHL was that in which workers are exposed to pesticides. We therefore conclude that the evidence synthesis of the epidemiological literature supports an increased risk for NHL, regardless of subtype, considering occupational exposure to certain chemical compounds, mainly pesticides, benzene, and trichlorethylene, and certain classes of work, primarily in the field of agriculture.
非霍奇金淋巴瘤（NHL）是一组具有不同疾病类型的异质性疾病。目前尚不清楚导致NHL发病率上升的原因，然而，已知接触化学物质是该疾病的风险因素之一。因此，我们进行了一项系统综述和荟萃分析，纳入病例对照、队列和横断面观察性流行病学研究，以验证职业接触致癌物与NHL风险之间的关联。收集了2000年至2020年间的文章。两名不同的评审员使用Rayyan QCRI网络应用程序对研究进行了盲选。完成后，通过RedCap平台提取并分析所选文章。我们的综述共得到2719篇文章，其中51篇纳入荟萃分析，总体OR为1.27（95%CI 1.04-1.55）。此外，观察到与NHL风险增加相关的主要职业是工人接触农药的职业。因此，我们得出结论，流行病学文献的证据综合表明，考虑到职业接触某些化合物，主要是农药、苯和三氯乙烯，以及某些工作类别，主要是农业领域的工作，无论亚型如何，NHL的风险都会增加。
