Kawano Daigo, Yoshino Ichiro, Shoji Fumihiro, Morodomi Yosuke, Yano Tokujiro, Maehara Yoshihiko
Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.
Gen Thorac Cardiovasc Surg. 2010 Feb;58(2):95-7. doi: 10.1007/s11748-009-0480-7. Epub 2010 Feb 13.
We here report a rare case of synovial sarcoma of the chest wall. A 71-year-old Japanese woman noticed a left anterior chest wall mass after twice having had surgery for lung cancer. An aspiration biopsy diagnosed synovial sarcoma. She then underwent a surgical resection. Pathology examination revealed a biphasic-type synovial sarcoma. When the prepared RNA from the tumor was subjected to a polymerase chain reaction, SYT-SSX1 fusion gene transcripts were demonstrated. Patients with the SYT-SSX1 fusion gene have a worse clinical outcome than patients with SYT-SSX2-positive tumors. After a second surgery, performed in 1 year later, there was no evidence of recurrence for 30 months; however, careful observation may be required.
我们在此报告一例罕见的胸壁滑膜肉瘤病例。一名71岁的日本女性在两次接受肺癌手术后发现左前胸壁肿物。穿刺活检诊断为滑膜肉瘤。随后她接受了手术切除。病理检查显示为双相型滑膜肉瘤。当对肿瘤制备的RNA进行聚合酶链反应时，证实存在SYT-SSX1融合基因转录本。与SYT-SSX2阳性肿瘤患者相比，具有SYT-SSX1融合基因的患者临床预后更差。在1年后进行第二次手术后，30个月内无复发迹象；然而，仍可能需要密切观察。
