AFSSA site de Niort, Laboratoire d'Etudes et de Recherches Caprines, 60 rue de Pied de Fond, BP 3081 79012 Niort, Cedex, France.
Parasitol Res. 2010 May;106(6):1475-9. doi: 10.1007/s00436-010-1781-6. Epub 2010 Feb 13.
Anthelmintic resistance is very prevalent in ruminant strongyle populations, especially in goats. Several occurrences of multiple anthelminthic resistances have been reported in goat flocks throughout the world, including resistance to the most recent macrocyclic lactones. A faecal egg count reduction test was conducted to detect resistance to ivermectin in French goat flocks. Thirty goats per flock were randomly selected in 22 flocks and allocated into two groups of 15 animals: an untreated control group and an ivermectin-treated group (0.3 mg/kg BW per os). Individual faecal egg counts and pooled larval cultures were performed 16-17 days after anthelmintic treatment for control and treated groups. FECR's were calculated for treated group vs. control one and when <95/100, were considered as indicative of anthelmintic resistance. FECR results indicated the absence of ivermectin resistance in nematode populations from all the 22 goat farms. The nematode genera involved in control groups were of Teladorsagia/Trichostrongylus, Haemonchus and Oesophagostomum/Chabertia types.
抗蠕虫药耐药性在反刍动物的 Strongyle 种群中非常普遍，特别是在山羊中。在世界各地的山羊群中已经报告了多次多种抗蠕虫药耐药性的发生，包括对最近的大环内酯类药物的耐药性。进行了粪便卵计数减少试验以检测法国山羊群对伊维菌素的耐药性。在 22 个羊群中，每个羊群随机选择 30 只山羊，并将它们分为两组，每组 15 只动物：未处理的对照组和伊维菌素处理组（口服 0.3 mg/kg BW）。在驱虫处理后 16-17 天，对对照组和处理组进行个体粪便卵计数和混合幼虫培养。当处理组的 FECR<95/100 时，计算处理组与对照组的 FECR，并认为这表明存在抗蠕虫药耐药性。FECR 结果表明，所有 22 个山羊场的线虫种群均未出现伊维菌素耐药性。对照组涉及的线虫属为 Teladorsagia/Trichostrongylus、Haemonchus 和 Oesophagostomum/Chabertia 型。
