Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd, 5-1-83 Higashihara, Zama, Kanagawa 228-8583, Japan.
Biometals. 2010 Jun;23(3):419-24. doi: 10.1007/s10534-010-9304-6. Epub 2010 Feb 14.
Lactoferrin (LF) is a component of saliva and is suspected to be a defense factor against oral pathogens including Streptococcus mutans and Candida albicans. Periodontitis is a very common oral disease caused by periodontopathic bacteria. Antimicrobial activities and other biological effects of LF against representative periodontopathic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia, have been widely studied. Association of polymorphisms in LF with incidence of aggressive periodontitis and the role of LF in the gingival crevicular fluid as a marker of periodontitis severity have also been reported. Periodontopathic bacteria reside as a biofilm in supragingival and subgingival plaque. Our recent study indicated that LF exhibits antibacterial activity against planktonic forms of P. gingivalis and P. intermedia at higher concentrations, and furthermore, LF effectively inhibits biofilm formation and reduces the established biofilm of these bacteria at physiological concentrations. A small-scale clinical study indicated that oral administration of bovine LF reduces P. gingivalis and P. intermedia in the subgingival plaque of chronic periodontitis patients. LF seems to be a biofilm inhibitor of periodontopathic bacteria in vitro and in vivo.
乳铁蛋白（LF）是唾液的成分之一，被怀疑是抵抗口腔病原体（包括变形链球菌和白色念珠菌）的防御因素。牙周炎是一种由牙周病细菌引起的非常常见的口腔疾病。LF 对代表性牙周病细菌，如伴放线放线杆菌、牙龈卟啉单胞菌和中间普氏菌的抗菌活性和其他生物学效应已得到广泛研究。LF 多态性与侵袭性牙周炎的发病机制以及 LF 在牙龈沟液中作为牙周炎严重程度标志物的作用也有报道。牙周病细菌以龈上和龈下菌斑生物膜的形式存在。我们最近的研究表明，LF 在较高浓度下对浮游形式的牙龈卟啉单胞菌和中间普氏菌表现出抗菌活性，此外，LF 还能有效抑制生物膜的形成，并降低这些细菌在生理浓度下已建立的生物膜。一项小规模的临床研究表明，口服牛乳铁蛋白可减少慢性牙周炎患者龈下菌斑中的牙龈卟啉单胞菌和中间普氏菌。LF 似乎是体外和体内牙周病细菌生物膜抑制剂。
