López-Valverde Nansi, López-Valverde Antonio, Montero Javier, Rodríguez Cinthia, Macedo de Sousa Bruno, Aragoneses Juan Manuel
Department of Medicine and Medical Specialties, Faculty of Health Sciences, Universidad Alcalá de Henares, Madrid, Spain.
Instituto de Investigación Biomédica de Salamanca (IBSAL), Madrid, Spain.
Front Bioeng Biotechnol. 2023 Aug 3;11:1226907. doi: 10.3389/fbioe.2023.1226907. eCollection 2023.
Periodontal diseases (PD) are common chronic inflammatory oral pathologies that are strongly linked to others not found in the mouth cavity. The immune system mediates the host response, which includes the upregulation of proinflammatory cytokines, metalloproteinases, and reactive oxygen species (ROS); the latter may play an important role in the establishment and progression of inflammatory diseases, particularly periodontal disease, via the development of oxidative stress (OS). Natural antioxidants have powerful anti-inflammatory properties, and some can reduce serum levels of key PD indicators such tumor necrosis factor (TNF) and interleukin IL-1. This review compiles, through a thorough literature analysis, the antioxidant, anti-inflammatory, and antibacterial effects of a variety of natural products, as well as their therapeutic potential in the treatment of PD.
牙周疾病（PD）是常见的慢性炎症性口腔疾病，与口腔外的其他疾病密切相关。免疫系统介导宿主反应，其中包括促炎细胞因子、金属蛋白酶和活性氧（ROS）的上调；后者可能通过氧化应激（OS）的发展在炎症性疾病尤其是牙周疾病的发生和发展中发挥重要作用。天然抗氧化剂具有强大的抗炎特性，有些可以降低关键牙周疾病指标如肿瘤坏死因子（TNF）和白细胞介素IL-1的血清水平。本综述通过全面的文献分析，汇总了多种天然产物的抗氧化、抗炎和抗菌作用，以及它们在治疗牙周疾病方面的治疗潜力。
