Ramon J, Goldwasser B, Raviv G, Jonas P, Many M
Department of Urology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Cancer. 1991 May 15;67(10):2506-11. doi: 10.1002/1097-0142(19910515)67:10<2506::aid-cncr2820671020>3.0.co;2-y.
From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent radical nephrectomy. The selection of the surgical procedure was based on the surgeon's preference and not on the basis of clinical stage, age, or sex. The surgical results and survival rates were assessed according to the pathologic stage of the tumors. Among patients with Stage I tumor, radical nephrectomy produced better survival rates at 5 and 10 years (P = 0.03); however, when the non-cancer deaths were excluded, the difference in survival was not statistically significant. For Stage I tumors the survival free of disease at 5 years was better for the radical nephrectomy group, but this difference was not statistically significant. No difference was noticed in the local recurrence rate between the two groups. Nephrectomy in patients with Stage IV disease did not alter survival regardless of the type of operation.
1974年至1983年期间，以色列特拉维夫哈绍梅尔市的海姆·谢巴医疗中心针对肾细胞癌实施了单纯性肾切除术和根治性肾切除术。作者回顾了109例随访时间为5至14年的病例。55例患者接受了单纯性肾切除术，54例患者接受了根治性肾切除术。手术方式的选择基于外科医生的偏好，而非临床分期、年龄或性别。根据肿瘤的病理分期评估手术结果和生存率。在I期肿瘤患者中，根治性肾切除术在5年和10年时的生存率更高（P = 0.03）；然而，排除非癌症死亡病例后，生存率的差异无统计学意义。对于I期肿瘤，根治性肾切除术组5年无病生存率更好，但这种差异无统计学意义。两组之间的局部复发率未发现差异。无论手术类型如何，IV期疾病患者的肾切除术均未改变生存率。
