University of Massachusetts Medical School, Worcester, MA, USA.
J Addict Dis. 2009 Jul;28(3):226-31. doi: 10.1080/10550880903014767.
The purpose of this article was to characterize practices of buprenorphine/naloxone (B/N) diversion in a region with a high prescribing prevalence. A cross-sectional, open-ended survey was administered to individuals entering opioid addiction treatment programs in two New England states. The authors obtained formative information about the knowledge, attitudes, beliefs, practices, and street economy of B/N diversion. The authors interviewed 51 individuals, 49 of which were aware of B/N medication. Of that number, 100% had diverted B/N to modulate opiate withdrawal symptoms arising from attempted "self-detoxification," insufficient funds to purchase preferred illicit opioids, or inability to find a preferred source of drugs. Thirty of 49 (61%) participants obtained the illicit drug from an individual holding a legitimate prescription for B/N. A high proportion of individuals in the study locations who sought treatment for opioid addiction self-reported the purchase and use of diverted B/N. The diversion of B/N may be minimized by modifying educational, treatment, monitoring, and dispensing practices.
本文旨在描述一个高处方流行地区丁丙诺啡/纳洛酮（B/N）转用的情况。在两个新英格兰州的阿片类药物成瘾治疗项目中，对进入项目的个人进行了横断面、开放式调查。作者获得了关于 B/N 转用的知识、态度、信念、实践和街头经济的形成性信息。作者采访了 51 人，其中 49 人了解 B/N 药物。在这一数字中，100%的人曾将 B/N 转用，以调节因试图“自我戒毒”、资金不足购买首选非法阿片类药物或无法找到首选毒品来源而引起的阿片类药物戒断症状。在研究地点，49 名参与者中有 30 名（61%）从持有 B/N 合法处方的个人那里获得了非法药物。寻求阿片类药物成瘾治疗的研究地点的个人中有很大一部分自我报告购买和使用了转用的 B/N。通过修改教育、治疗、监测和配药实践，可以最大限度地减少 B/N 的转用。
