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植物化学物质在肝细胞癌预防中的作用。

Phytochemicals in hepatocellular cancer prevention.

机构信息

Kyoto Prefectural University of Medicine and Ritsumeikan University, Kamigyo-ku, Kyoto, Japan.

出版信息

Nutr Cancer. 2009;61(6):789-91. doi: 10.1080/01635580903285031.

DOI:10.1080/01635580903285031
PMID:20155617
Abstract

Since the incidence of liver cancer is increasing in the world, it is valuable to develop an effective method for its prevention. Various phytochemicals have been shown to suppress liver carcinogenesis in experimental studies. Using these phytochemicals, a clinical trial was conducted. Combination of carotenoids and myo-inositol was found to prevent hepatocellular carcinoma development in patients with chronic viral hepatitis and cirrhosis.

摘要

由于全球肝癌发病率不断上升,因此开发有效的预防方法具有重要价值。在实验研究中,各种植物化学物质已被证明可抑制肝癌的发生。基于这些植物化学物质,开展了一项临床试验。结果发现,类胡萝卜素和肌醇的联合使用可预防慢性病毒性肝炎和肝硬化患者发生肝细胞癌。

相似文献

1
Phytochemicals in hepatocellular cancer prevention.植物化学物质在肝细胞癌预防中的作用。
Nutr Cancer. 2009;61(6):789-91. doi: 10.1080/01635580903285031.
2
Prevention of hepatocellular carcinoma in chronic viral hepatitis patients with cirrhosis by carotenoid mixture.
Recent Results Cancer Res. 2007;174:67-71. doi: 10.1007/978-3-540-37696-5_6.
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Potential role of lycopene in the treatment of hepatitis C and prevention of hepatocellular carcinoma.番茄红素在丙型肝炎治疗及肝细胞癌预防中的潜在作用。
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Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis.维生素K2对丙型肝硬化患者肝细胞癌发生发展的影响。
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Growth inhibitory efficacy of lycopene and β-carotene against androgen-independent prostate tumor cells xenografted in nude mice.番茄红素和β-胡萝卜素对裸鼠移植的雄激素非依赖性前列腺癌细胞生长抑制作用。
Mol Nutr Food Res. 2011 Apr;55(4):606-12. doi: 10.1002/mnfr.201000308. Epub 2010 Dec 20.
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Colchicine delays the development of hepatocellular carcinoma in patients with hepatitis virus-related liver cirrhosis.秋水仙碱可延缓肝炎病毒相关性肝硬化患者肝细胞癌的发展。
Cancer. 2006 Oct 15;107(8):1852-8. doi: 10.1002/cncr.22198.
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Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.
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Prevention of the occurrence of hepatocellular carcinoma in patients with cirrhosis.预防肝硬化患者肝细胞癌的发生。
Hepatogastroenterology. 1998 Aug;45 Suppl 3:1291-5.
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Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol.通过口服肌醇抑制小鼠肺癌和肝癌的发生。
Anticancer Res. 1999 Sep-Oct;19(5A):3663-4.
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The risk of liver and bile duct cancer in patients with chronic viral hepatitis, alcoholism, or cirrhosis.慢性病毒性肝炎、酒精中毒或肝硬化患者患肝癌和胆管癌的风险。
Hepatology. 2001 Oct;34(4 Pt 1):714-8. doi: 10.1053/jhep.2001.28233.

引用本文的文献

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Specific botanical groups of fruit and vegetable consumption and liver cancer and chronic liver disease mortality: a prospective cohort study.特定水果和蔬菜植物群的消费与肝癌和慢性肝病死亡率:一项前瞻性队列研究。
Am J Clin Nutr. 2023 Feb;117(2):278-285. doi: 10.1016/j.ajcnut.2022.12.004. Epub 2022 Dec 22.
2
Cancer Prevention by Natural Products Introduced into the Diet-Selected Cyclitols.天然产物在饮食中的引入对癌症的预防作用-选择环糖醇。
Int J Mol Sci. 2020 Nov 26;21(23):8988. doi: 10.3390/ijms21238988.
3
Carotenoids in Cancer Apoptosis-The Road and Back.
癌症凋亡中的类胡萝卜素——来路与归途
Cancers (Basel). 2020 Aug 26;12(9):2425. doi: 10.3390/cancers12092425.
4
American Ginseng ( L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties.西洋参(L.)作为具有健康促进特性的生物活性植物化学物质的来源。
Nutrients. 2019 May 9;11(5):1041. doi: 10.3390/nu11051041.
5
Terpenoids as potential chemopreventive and therapeutic agents in liver cancer.萜类化合物作为肝癌潜在的化学预防和治疗药物。
World J Hepatol. 2011 Sep 27;3(9):228-49. doi: 10.4254/wjh.v3.i9.228.
6
Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model.新鲜覆盆子植物化学提取物可抑制 Wistar 大鼠模型的肝损伤。
Nutr Metab (Lond). 2010 Nov 25;7:84. doi: 10.1186/1743-7075-7-84.