Seren Soley, Mutchnick Milton, Hutchinson Daryl, Harmanci Ozgur, Bayraktar Yusuf, Mutchnick Sean, Sahin Kazim, Kucuk Omer
Department of Medicine, Wayne State University, Detroit, MI, USA.
Nutr Cancer. 2008;60(6):729-35. doi: 10.1080/01635580802419772.
Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.
丙型肝炎病毒（HCV）感染和肝细胞癌（HCC）在全球范围内正成为日益严重的健康问题。氧化应激在肝细胞损伤的起始和进展中起着重要作用，并且可能在HCV感染患者的HCC发生过程中也发挥作用。体外、动物和临床研究表明，番茄红素，一种非维生素A类胡萝卜素且是一种强效抗氧化剂，可能减轻肝损伤并有可能预防HCC的发生。在本文中，我们讨论了HCV感染与氧化应激之间的关系，并综述了番茄红素在治疗HCV和预防HCC方面的潜在作用。
