Le Scanff Julie, Vighetto Alain, Mekki Yahia, Nguyen Anh Minh, Dufour Jean-François, Broussolle Christiane, Seve Pascal
Department of Internal Medicine, Hospices Civils de Lyon, and University Claude Bernard, Lyon 1, France.
Eur J Ophthalmol. 2010 Jul-Aug;20(4):802-4. doi: 10.1177/112067211002000428.
Parvovirus B19 infection (PVB19) has been linked with a broad spectrum of clinical syndromes. In addition to erythema infectiosum and asymptomatic infection, other less common manifestations include transient aplastic crisis in patients with hemoglobinopathies, pure red cell aplasia and pancytopenia in immunocompromised persons, nonimmune hydrops fetalis, chronic arthritis, myocarditis, and hepatitis.
Only 19% of patients had peripheral nervous system damage, mainly including brachial plexitis and carpal tunnel syndrome. Two cases of cranial nerves palsies have been described in children in the literature, including one case of peripheral facial nerve palsy and one case of velopalatine hemiparalysis. We report the first case of acute ophthalmoparesis associated with PVB19 infection.
We present a 40-year-old man with PVB19 with acute sixth cranial nerve palsy, diagnosed on the basis of serology and polymerase chain reaction carried out both on serum and cerebrospinal fluid.
Clinicians should be aware of this possible clinical presentation.
细小病毒B19感染（PVB19）与多种临床综合征相关。除传染性红斑和无症状感染外，其他较不常见的表现包括血红蛋白病患者的短暂再生障碍危象、免疫功能低下者的纯红细胞再生障碍和全血细胞减少、非免疫性胎儿水肿、慢性关节炎、心肌炎和肝炎。
仅19%的患者有周围神经系统损害，主要包括臂丛神经炎和腕管综合征。文献中已描述了两例儿童颅神经麻痹病例，包括一例周围性面神经麻痹和一例腭帆半麻痹。我们报告首例与PVB19感染相关的急性眼肌麻痹病例。
我们报告一名40岁患有PVB19感染的男性，伴有急性第六颅神经麻痹，根据血清学以及血清和脑脊液进行的聚合酶链反应确诊。
临床医生应意识到这种可能的临床表现。
