Yüksel Bora, Bozdağ Berkant, Acar Memed, Topaloğlu Engin
Eye Bank and Cornea Section, Izmir Bozyaka Teaching and Research Hospital, Bozyaka-Izmir, Turkey.
Eur J Ophthalmol. 2010 Jul-Aug;20(4):675-9. doi: 10.1177/112067211002000405.
This study evaluated the efficacy of topical cyclosporine A 0.05% treatment with impression cytology in dry eye patients.
Forty eyes of 40 patients with dry eye were included. Schirmer tear break-up time, and Ocular Surface Disease Index (OSDI) scores and goblet cell densities were noted before and after 6 months of topical cyclosporine A treatment. Patients were graded clinically and biomicroscopically as follows: grade 1, 12 patients; grade 2, 18; and grade 3, 10 patients.
Mean age was 57.1 +/- 11.8 (23.0-80.0) years. A total of 36 (90%) of the patients were female and 4 (10%) were male. Mean Schirmer test value was 3.2 +/- 1.6 (0.0-8.0) mm in the beginning and was 8.4 +/- 4.3 (1.0-19.0) mm after 6 months of cyclosporine A topical treatment (p = 0.00). At the first visit, mean tear break-up time was 4.4 +/- 1.8 (2.0-8.0) seconds. It increased to 11.8 +/- 4.8 (2.0-20.0) seconds at the end of the sixth month (p = 0.00). Mean clinical grading was 1.9 +/- 0.8 (1.0-3.0) and this value regressed to 0.8 +/- 1.2 (0.0-3.0) after the treatment (p = 0.00). Mean OSDI score was 30.0 +/- 11.7 (9.0-50.0) before the treatment and 21.3 +/- 11.0 (4.0-47.0) after the treatment (p = 0.00). Mean goblet cell density of all cases was 12.3 +/- 8.7 before the treatment (2.0-28.0). It increased to 33.0 +/- 25.4 (6-70) after the treatment (p = 0.04).
Topical cyclosporine A treatment is effective in grade 1 and grade 2 dry eye patients but results are poor in grade 3 patients.
本研究评估了0.05%局部用环孢素A联合印迹细胞学检查对干眼症患者的疗效。
纳入40例干眼症患者的40只眼。记录局部用环孢素A治疗6个月前后的泪液分泌试验、泪膜破裂时间、眼表疾病指数（OSDI）评分和杯状细胞密度。对患者进行临床和生物显微镜分级如下：1级，12例患者；2级，18例；3级，10例患者。
平均年龄为57.1±11.8（23.0 - 80.0）岁。共有36例（90%）患者为女性，4例（10%）为男性。开始时泪液分泌试验平均值为3.2±1.6（0.0 - 8.0）mm，局部用环孢素A治疗6个月后为8.4±4.3（1.0 - 19.0）mm（p = 0.00）。首次就诊时，平均泪膜破裂时间为4.4±1.8（2.0 - 8.0）秒。在第六个月末增加到11.8±4.8（2.0 - 20.0）秒（p = 0.00）。平均临床分级为1.9±0.8（1.0 - 3.0），治疗后该值降至0.8±1.2（0.0 - 3.0）（p = 0.00）。治疗前平均OSDI评分为30.0±11.7（9.0 - 50.0），治疗后为21.3±11.0（4.0 - 47.0）（p = 0.00）。所有病例的平均杯状细胞密度治疗前为12.3±8.7（2.0 - 28.0）。治疗后增加到33.0±25.4（6 - 70）（p = 0.04）。
局部用环孢素A治疗对1级和2级干眼症患者有效，但对3级患者效果不佳。
