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局部应用环孢素A治疗与慢性移植物抗宿主病相关的干眼症。

Topical cyclosporine-A in dry eye associated with chronic graft versus host disease.

作者信息

Kurt Rengin Aslihan, Yalçindag Nilüfer, Atilla Huban, Arat Mutlu

机构信息

Ankara University, Faculty of Medicine, Department of Ophthalmology, Dikimevi, Ankara, Turkey.

出版信息

Ann Ophthalmol (Skokie). 2009 Fall-Winter;41(3-4):166-9.

PMID:20214049
Abstract

We evaluated the efficacy and safety of topical cyclosporine-A in dry eye associated with chronic graft versus host disease (GVHD) in 8 patients. Visual acuity, fluorescein staining of cornea and conjunctiva, tear break-up time, Schirmer test results and subjective complaints were recorded. Topical cyclosporine-A might be an effective and safe treatment option in dry eye related to chronic GVHD.

摘要

我们评估了8例慢性移植物抗宿主病(GVHD)相关干眼患者局部应用环孢素A的疗效和安全性。记录了视力、角膜和结膜的荧光素染色、泪膜破裂时间、泪液分泌试验结果及主观症状。局部应用环孢素A可能是慢性GVHD相关性干眼的一种有效且安全的治疗选择。

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Ann Ophthalmol (Skokie). 2009 Fall-Winter;41(3-4):166-9.
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引用本文的文献

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Indian J Ophthalmol. 2023 Apr;71(4):1538-1544. doi: 10.4103/IJO.IJO_2820_22.
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Role of topical and systemic immunosuppression in aqueous-deficient dry eye disease.局部和全身免疫抑制在水液缺乏性干眼疾病中的作用。
Indian J Ophthalmol. 2023 Apr;71(4):1176-1189. doi: 10.4103/IJO.IJO_2818_22.
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Risk stratification of organ-specific GVHD can be improved by single-nucleotide polymorphism-based risk models.
基于单核苷酸多态性的风险模型可提高器官特异性移植物抗宿主病的风险分层。
Bone Marrow Transplant. 2014 May;49(5):649-56. doi: 10.1038/bmt.2014.20. Epub 2014 Mar 3.
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Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease.间充质基质细胞治疗可减轻慢性移植物抗宿主病患者的干眼症状。
Mol Ther. 2012 Dec;20(12):2347-54. doi: 10.1038/mt.2012.208. Epub 2012 Oct 16.
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Allogeneic serum eye drops for the treatment of dry eye patients with chronic graft-versus-host disease.同种异体血清滴眼液治疗慢性移植物抗宿主病干眼患者。
J Ocul Pharmacol Ther. 2012 Oct;28(5):479-83. doi: 10.1089/jop.2012.0002. Epub 2012 Jun 25.